About 31 results found for searched term "Endothelin Receptor" (0.102 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25441 | Recombinant Human Endothelin B Receptor Protein (HEK293, His Tag) | Recombinant Proteins |
| human EDNRB | ||
| EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. The recombinant human EDNRB consists 86 amino acids and predicts a molecular mass of 9.5 kDa. A DNA sequence encoding the human EDNRB (NP_000106.1) (Met1-Lys101) was expressed with a polyhistidine tag at the C-terminus. | ||
| M1816 | Zibotentan | Endothelin Receptor |
| ZD4054 | ||
| Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. | ||
| M1951 | Ambrisentan | Endothelin Receptor |
| BSF 208075; LU 208075 | ||
| Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor. | ||
| M2029 | Sitaxsentan sodium | Endothelin Receptor |
| TBC-11251 | ||
| Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2467 | Bosentan | Endothelin Receptor |
| Benzenesulfonamide; Ro-47-0203 | ||
| Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M5135 | Ro-46-2005 | Endothelin Receptor |
| Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. | ||
| M7665 | BMS-207940 | Others |
| BMS-207940 is a very potent and selective ETA endothelin receptor antagonist. | ||
| M7675 | BMS-248360 | Others |
| BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors. | ||
| M8058 | PD-156707 | Others |
| PD-156707 is a selective endothelin receptor (ETA) antagonist. | ||
| M8766 | Atrasentan hydrochloride | Endothelin Receptor |
| ABT-627 hydrochloride; Abbott 147627 | ||
| Atrasentan hydrochloride (ABT-627 hydrochloride) is a potent, orally active, selective endothelin A (ETA) receptor antagonist that inhibits ETA activity and blocks endothelin-induced cellular proliferation with an IC50 value of 0.0551 nM. It can be used in studies related to prostate cancer as well as IgA nephropathy (IgAN). It can be used in prostate cancer and IgA nephropathy (IgAN) related studies. | ||
| M9554 | BQ-123 | Endothelin Receptor |
| BQ-123 is a selective endothelin A receptors (ETAR) antagonist with an IC50 value of 7.3 nM. | ||
| M9792 | Sarafotoxin S6c | Endothelin Receptor |
| Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively). | ||
| M10916 | RO 46-8443 | Endothelin Receptor |
| RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | ||
| M11379 | Endothelin-3, human, mouse, rabbit, rat TFA | Peptides |
| Endothelin 3 (Rat, Human) (TFA) | ||
| Endothelin-3, human, mouse, rabbit, rat TFA is a vasoactive peptide composed of 21 amino acids that can bind to g-protein linked transmembrane receptors, ET-RA and ET-Rb. | ||
| M13960 | Endothelin 1 (swine, human) (TFA) | Endothelin Receptor |
| Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB. | ||
| M20689 | Sparsentan (RE-021) | Endothelin Receptor |
| PS-433540; RE-021; DARA-a; BMS-346567 | ||
| Sparsentan (PS-433540, RE-021, DARA) is a first-in-class, orally active, high-affinity dual antagonist of the endothelin type A receptor (ETA) and Angiotensin II type 1 (AT1) receptor, with Ki values of 9.3 and 0.8 nM, respectively. | ||
| M21788 | Atrasentan | Endothelin Receptor |
| ABT-627 | ||
| Atrasentan is a selective, orally active endothelin A (ETA) receptor antagonist. It can be used in studies related to glomerular disease and diabetic nephropathy. | ||
| M25449 | IRL-1620 TFA | Endothelin Receptor |
| IRL-1620 Trifluoroacetate; Sovateltide TFA | ||
| IRL-1620 TFA is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. | ||
| M40488 | K-8794 | Endothelin Receptor |
| K-8794 is an endothelin receptor ETB antagonist that may be used in studies related to heart failure. | ||
| M40489 | BQ-3020 ammonium | Endothelin Receptor |
| BQ-3020 ammonium is an endothelin receptor ETB agonist and induces endothelium-dependent vasodilation, which can be used in studies related to cardiovascular disease. | ||
| M40485 | LAS-103 | Endothelin Receptor |
| LAS-103 is an endothelin receptor ETB antagonist that may be used in studies related to breast cancer. | ||
| M28815 | IRL 2500 | Endothelin Receptor |
| IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. | ||
| M28831 | Darusentan | Endothelin Receptor |
| Lu-135252 | ||
| Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM. | ||
| M28888 | Tezosentan | Endothelin Receptor |
| RO 610612 | ||
| Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. | ||
| M28942 | Sitaxsentan | Endothelin Receptor |
| IPI 1040; TBC-11251 | ||
| Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure. IC50 value: Target: ETA receptor | ||
| M29057 | A-192621 | Endothelin Receptor |
| A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level. | ||
| M40484 | ENB-005 | Endothelin Receptor |
| ENB-005 is an endothelin receptor ETB antagonist that can be used in studies related to brain metastases. | ||
| M40483 | ENB-003 | Endothelin Receptor |
| ENB-003 is an endothelin receptor ETB antagonist that may be used in melanoma-related studies. | ||
| M40482 | VRP-1620 | Endothelin Receptor |
| VRP-1620 is an endothelin receptor ETB antagonist that may be used in studies related to breast cancer. | ||
| M40490 | IRL-1038 | Endothelin Receptor |
| IRL-1038 is a selective endothelin receptor ETB antagonist for studies related to cardiovascular disease. | ||
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